Gap junction reduction in cardiomyocytes following transforming growth factor- β treatment and Trypanosoma cruzi infection
نویسندگان
چکیده
1Laboratório de Inovações Terapêuticas, Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro, RJ, Brasil 2Autonomic Neuroscience Centre, Royal Free and University College Medical School, Rowland Hill Street, London, UK 3Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil 4Institut National de la Santé et de la Recherche Médicale, Unité 878, and Commissariat à l’Énergie Atomique, Institut de Recherches en Technologies et Sciences pour le Vivant, Grenoble, France 5Instituto do Coração, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil 6Department of Anatomy and Developmental Biology, University College London, Gower Street, London, UK
منابع مشابه
Gap junction reduction in cardiomyocytes following transforming growth factor-beta treatment and Trypanosoma cruzi infection.
Gap junction connexin-43 (Cx43) molecules are responsible for electrical impulse conduction in the heart and are affected by transforming growth factor-beta (TGF-beta). This cytokine increases during Trypanosoma cruzi infection, modulating fibrosis and the parasite cell cycle. We studied Cx43 expression in cardiomyocytes exposed or not to TGF-beta T. cruzi, or SB-431542, an inhibitor of TGF-bet...
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